Information for Researchers

Overview

Quantitative neuroimaging infrastructure for research-grade measurement at clinical scale

Harmonized, analysis-ready measurement

BrainScores transforms multisite MRI into harmonized, analysis-ready measurements for cohort studies, clinical trials, and biomarker discovery. Our pipelines combine rigorous metadata capture, automated processing, quality control, normative modeling, and interpretable outputs built on peer-reviewed neuroimaging science.

Reliable across sites and studies

Research MRI is powerful, but multisite data are messy. Scanner differences, protocol drift, missing metadata, variable quality, and inconsistent processing can obscure real biological signal. BrainScores is designed to make subtle neuroanatomical measurement reliable across sites, studies, and patient populations.

Capabilities

A complete pipeline from raw MRI to study-ready results

Automated MRI processing

  • Standardized pipelines for structural MRI, multimodal imaging, morphometry, and quality control.
  • Built to accommodate real-world scanner and protocol variability where appropriate.

Harmonized measurement

  • Generate comparable cortical, subcortical, and whole-brain features across subjects and sites.
  • Support age-adjusted and population-aware comparisons for cohort-level analysis.

Normative and deviation modeling

  • Quantify where an individual or subgroup differs from expected anatomical patterns.
  • Useful for enrichment, stratification, endpoint exploration, and mechanistic subgroup discovery.

Study-ready outputs

  • Deliver clean tables, QC reports, visual summaries, and analysis-ready exports for statistical teams.
Clinical trial

Clinical trial enrichment

Find the participants most likely to show measurable brain change — built for Clinical Research Organizations (CROs) and trial sponsors.

Identify imaging-defined subgroups to target the participants most likely to respond.

Quantify baseline abnormality to establish a clear structural starting point for each participant.

Track structural change over time to detect treatment effect as it emerges.

For diseases where treatment effect depends on stage, subtype, or regional vulnerability, quantitative MRI can help enrich cohorts and reduce measurement noise.

Applications

Potential applications

01

Baseline enrichment

Enrich trial baselines using structural deviation, atrophy, asymmetry, or lesion burden.

02

Participant stratification

Stratify participants by imaging phenotype.

03

Longitudinal monitoring

Monitor regional change over time.

04

Exploratory endpoints

Support exploratory endpoints for early-phase trials.

05

Retrospective analysis

Analyze existing cohorts retrospectively to assess imaging signal before prospective deployment.

Credibility

Built on data from leading research institutions worldwide

0+Partner research institutions
0+Open-source software downloads
0+Peer-reviewed citations
CHU Sainte-Justine
BC Children's Hospital
UNIMORE
ENIGMA
Hospital General de México
Montreal Neurological Institute
McGill University Health Centre
University of California
Alberta Children's Hospital
Nanjing Central Hospital
Western University
Toronto Baycrest
CHU Sainte-Justine
BC Children's Hospital
UNIMORE
ENIGMA
Hospital General de México
Montreal Neurological Institute
McGill University Health Centre
University of California
Alberta Children's Hospital
Nanjing Central Hospital
Western University
Toronto Baycrest
Contact

Partner with us on your next study

Talk with our research team about data partnerships, harmonization protocols, cohort collaborations, or academic access to the BrainScores platform.